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LGD 4033 was developed with the goal of preventing muscle loss in the elderly and in those who suffer from muscle dystrophy. The purpose of this study was to determine the possible clinical benefits of LDN in the treatment of skeletal muscle atrophy (SMAD), a rare autosomal dominant disease of skeletal muscle in which an abnormal protein is found in the mitochondria responsible for powering the cell.

METHODS:

A total of 28 healthy volunteers (16 men age 65 to 72 y, 16 women age 65 to 73 y) underwent a 2-week treatment to be randomized and allocated into the placebo group, which received LDN, or the treatment group which received either placebo or a combination of LDN and L-arginine (LA), lgd 4033 buy usa. Both the group assigned to take LDN and the group assigned to do not take LDN had muscle biopsy (12 and 14 weeks after the end of trial). Muscle biopsy samples were taken every 4 weeks for 28 weeks, trenbolone sarm.

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L-arginine at a level of about 30 mg daily is effective enough to prevent muscle atrophy in patients suffering from SMAD, lgd 3303 vs 4033. The LDN (n = 12) was significantly superior to LA (n = 14) in reducing muscle atrophy.

CONCLUSIONS:

LDN appears to be safe and well-tolerated in patients prone to muscle atrophy.

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